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This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]

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Targeting of STAT3 and STAT5 by a novel drug- combination employing ponatinib and bardoxolone methyl (CDDO-Me) leads to synergistic effects in BCR/ABL-T315I-mutated cells in Ph+ CML